Representative research projects, ex. 3: Research consortium JaBaS (2021-2024)
The JaBaS collaborative project (“Janus particle-based biosensor for next-generation monitoring of pharmaceutical pollutants”; FKZ: 031B1118A) is funded by the German Federal Ministry of Education and Research (BMBF) as part of the program "Future Technologies for the Industrial Bioeconomy - Biohybrid Technologies" (https://www.ptj.de/projektfoerderung/biooekonomie/zukunftstechnologien).
Other partners in the consortium are the Bavarian Polymer Institute (BPI) Bayreuth and the BTU Cottbus-Senftenberg. Respective research deals with the development of a coating and fabrication process for micro- and nanostructured semiconductor sensor-arrays based on geometrically and chemically anisotropic biohybrid Janus particles by immobilizing oxygen-incorporating enzymes of the peroxygenase type (a so-called biocatalytic "oxyfunctionalization tool"). In this context, a special "two-faced" immobilization technique opens access to previously unavailable enzyme-based biosensors that extend the scope of classical electrochemistry. Thus, fungal enzymes immobilized on particles can be used for the electrochemical detection and quantification of micro-pollutants (e.g. resistance-inducing disinfectants or pharmaceuticals) in environmental samples; i.e. substances that cause serious environmental damage even in very low concentrations.